![]() A summary of all SNPs reaching P < 5 × 10 −8 in UKB can be found in table S2. We report validated associations that meet genome-wide significance in the meta-analysis of UKB and GERA, which also demonstrate nominal association with the same direction of effect in GERA ( Table 1). We then carried forward lead SNPs at P < 5 × 10 −6 from UKB to Genetic Epidemiology Research in Adult Health and Aging (GERA) for replication. 1, inset), although linkage disequilibrium (LD) score regression intercept = 1.02 suggests most of the inflation is consistent with polygenic architecture. The GWAS data test statistics showed modest deviation from the null (λ GC = 1.09 Fig. A total of 11,141,077 SNPs survived central quality control (QC) by UKB and post-GWAS filtering for imputation quality and minor allele frequency. ![]() We tested for SNP-level association with our high alcohol consumption phenotype in UKB. These findings offer insight into genes, pathways, and relationships for disease risk associated with high alcohol consumption. Evidence of causal links to lung cancer, and shared genetic architecture with gout and hypertension was also found. A conserved role in phenotypic responses to alcohol was observed for all genetic targets available for investigation ( ADH1B, GCKR, SLC39A8, and KLB) in Caenorhabditis elegans. We identified six loci attaining genome-wide significant association with alcohol consumption after meta-analysis and meeting our criteria for replication: ADH1B (lead SNP: rs1229984), KLB (rs13130794), BTF3P13 (rs144198753), GCKR (rs1260326), SLC39A8 (rs13107325), and DRD2 (rs11214609). Biobank ( n = 125,249) and GERA ( n = 47,967) datasets to determine genetic factors associated with extreme population-level alcohol consumption and examine the functional validity of outcomes using model organisms and in silico techniques. The capability of solution and low temperature processing for ECDs has the ability to significantly influence the industrialization of large-area smart windows.High alcohol consumption is a risk factor for morbidity and mortality, yet few genetic loci have been robustly associated with alcohol intake. Very good energy-savings were achieved and an all-organic smart window with excellent characteristics was verified. The heat-shielding characteristics (86.2%) were also excellent. When fabricated using the roll-to-roll method, a large-area smart window of 500 × 500 mm 2 was produced. The characteristics of these materials and devices have significant applicability as large-area smart windows. An excellent coloration efficiency value (1872.8 cm 2 C –1 at 600 nm) was obtained with low-power consumption (102 μW cm –2 (coloration) and 11 μW cm –2 (bleaching)). The ECD showed excellent optical characteristics and cycle stability owing to the balanced surface charge capacity (insertion/exertion). The polymer layer used was PEDOT:PSS and PANI:PSS, which alone can serve as an electrode and an EC layer, without the need for other electrode materials (ITO, FTO, etc.). In this study, an ECD was fabricated on a PET film by a solution process using a multifunctional conducting polymer synthesized by oxidation polymerization. However, because smart windows are not optimized for high performance, and most are manufactured based on glass form, the large-area manufacturing process is complex and hinders its applicability to electrochromic (EC) devices. ![]() They can dynamically control solar radiation consumption in buildings and vehicles to enhance efficiency. Electrochromic devices (ECDs) exhibit significant potential as emerging electronics for applications associated with smart windows.
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